volume6issue22020

Research in Pharmacy and Health Sciences, Volume 6, Issue 2: Apr-Jun, 2020

1.Hepatoprotective activity of Mentha arvensis in anti-tubercular drugs induced hepatotoxicity in rats
Sartaj Ahmad Mir, G. Jeyabalan, Gazala Parveen, Mujeeb Ur Rahman*

DOI: https://doi.org/10.32463/RPHS.2020.v06i02.01

Abstract
Mentha arvensis L. (Lamiaceae), usually known as Pudina, and traditionally used for various therapeutic purposes like food seasoner, household remedy, and industrial purposes, etc. The present study appraised the hepatoprotective activity of the methanol extract of Mentha arvensis L. (MEMA) against isoniazid and rifampicin (50 mg INH–100 mg RMP) induced liver impairment in rats. The dose of MEMA was 500 and 1000mg/kg daily for 28days given by orally and Silymarin as a standard drug (100 mg/kg) was used. On basis of the biochemical estimation of liver function tests (SGPT, SGOT, ALP, total protein and total billirubin), antioxidant assays of liver homogenate (lipid peroxidation, reduced glutathione content, superoxide dismutase, and catalase activity) and histological study of liver tissue, the hepatoprotective activity were evaluated. The treated animals, the toxicity of INH were controlled prominently by the restoration of the biochemical parameters as well as by the improvement of the antioxidant status as normal values. The results demonstrate that the methanol extract of Mentha arvensis has hepatoprotective activity against INH induced hepatotoxicity in rats.

2.A pandemic associated with novel coronavirus of probable animal origin
Navroop Kaur*, Saurabh Kumar Jha, Premnidhi Yadav, Soni Mishra, Umar Farooq, Umme Salma Siddiqui, Mohammad Zuhaib, Arshi Amin, Niraj Kumar Jha, Ankur Sharma

DOI: https://doi.org/10.32463/RPHS.2020.v06i02.02. 

Abstract
Emerging infectious diseases, such as (SARS) Severe Acute Respiratory Syndrome coronavirus and (MERS) Middle East Respiratory Syndrome coronavirus, it is the third extremely pathogenic coronavirus which is emerged in the last two decades. Epidemiological investigation recommended that coronavirus outbreak was associated with seafood marked in Wuhan, China. The patient suffering from coronavirus experience various respiratory syndrome symptoms including temperature, faintness and cough. Since, the cause of coronavirus was unknown. The analysis of pneumonia was unidentified, and pneumonia was identifying depending on clinical characteristics, ruling out of common bacterial, viral pathogens, and chest imaging that causes pneumonia. Some more cases were confirmed in China, Japan, the USA, and India. In today’s, Wuhan, China there is a possibility of the SARS-CoV outbreak without any earlier notice. To prevent this epidemic various cases from different countries should implement better triage schemes for imported cases of SARS -CoV. Some precautions like N95 masks were used for aerosol-generating diseases. One of the experimental antiviral agent Remdesivir drug shows significant activity against coronavirus in vitro. There is no exact treatment for this virus infection, however, it can relieve symptoms by taking over the counter medicine for pain, fever, and cough, using a room humidifier. As there is no exact treatments are available for this virus, initial control, and prevention of more spread will be critical to halt the outbreak and to control the spread of this coronavirus infections.

3.Assess the Awareness of Physiotherapists Regarding the Effects and Utilization of Different Physical Therapy Strategies Among Stroke Survivals in Karachi, Pakistan
Suneel Kumar, Muhammad Umair Shaikh, Aadil Ameer Ali*, Suman Shaikh, Muhammad Ishaque M.R and Shabana Yasmeen

DOI: https://doi.org/10.32463/RPHS.2020.v06i02.03

Abstract
Stroke is known as cerebro vascular accident (CVA). It’s focused neurological deficit which usually happens due to lack of blood supply towards the brain. Physical therapy is a successful way to rehabilitate the patients and brings him back to normal life. A cross-sectional survey was conducted in different hospitals of Karachi, data was collected from January to May 2014. A self-constructed proforma was filled by 100 physiotherapists, and Spss version 23 was used. The majority (n=64, 64%) were male and (n=69, 69%) belongs to age group of 34- 44. In marital status (n=79, 79%) were married, in education (n=78, 78%) were post-graduate. After checking their awareness we found that the majority (n=84, 84%) were aware. The study finalized that majority of physiotherapists were aware of the effects and utilization of different physical therapy strategies used among stroke survivals.

4.RETRACTION NOTICE

DOI: https://doi.org/10.32463/RPHS.2020.v06i02.04

Abstract
The research article entitled “Comparative Assessment of Amodiaquine and Quinine Sulphate Microspheres in The Treatment of Leishmaniasis” by Kesse S, Boakye-Yiadom KO, Farooq MA, Aquib M, Filli MS, Bo W. Research in Pharmacy and Health Sciences.2019;5(1):101- 106., doi: https:/doi.org/10.32463/rphs.2019.v05i01.01 [1] is retracted.
After the above article was published, one of the readers reported that the authors had published the same article in the World Journal of Pharmaceutical Research. 2018;14(7):90-103. [2]
The Research in Pharmacy and Health Sciences (RPHS) journal further investigated the publication in the World Journal of Pharmaceutical Research and found that the afore mentioned manuscript was self plagiarized with a modified title. The corresponding author of the manuscript was contacted by RPHS journal multiple times for clarification, but he failed to respond. The RPHS journal editors have thus agreed that Dr. Bo violated the journal policy and the self-plagiarized manuscript be retracted from the RPHS website. RPHS’ decision will be communicated to the corresponding author of the manuscript Dr. Bo, Head, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, CHINA.