The objective of the present study was to formulate and evaluate polyherbal tea granules for their physicochemical properties, stability, and antioxidant activity. The polyherbal tea granules were prepared by the wet granulation method and contained starch (rice broth) and natural plant leaves of moringa, tea, giloy, bay leaves, clove oil, and cardamom. The tea granules were subjected to phytochemical screening, quantitative phytoconstituent analysis, and several evaluation parameters like tapped density, bulk density, Hauser’s ratio, Carr’s index, disintegration, and moisture content. All formulations (F1, F2, F3, F4, and F5) are acceptable, but F2 is best in phytochemical screening according to the F1, F3, F4, and F5 formulations. The result of all evaluation parameters was evaluated to an acceptable limit, and a quantitative test of herbal tea granules is going on. The current formulation reveals an antioxidant response by the oral route of administration in water. Formulation to be the supplement of tea simultaneously stimulation response.

Keywords: herbal tea,antioxidant activity, therapeutics uses, moringa, giloy, cardamom, tea, clove-oil and bay leave etc…….

Darunaj-aqrabi (Doronicum hookeri CB Clarke ex. Hook.f.) is a medicinal plant (Asteraceae) that has long been used in the Unani Medicine System (USM) to produce cardiac tonic (rejuvenating and stimulant), nerve tonic, carminative, embryo protective, antidote, etc. functions in various formulations. It is extremely valuable for palpitations, so it is included in medicines specific to the heart. Due to their anti-inflammatory and protective properties (repair), rhizomes are widely utilised in compound formulations that have a tonic effect on the body. The main objective of this review is to show the significance of Darunaj-aqrabi in USM. This review provides important information focusing on traditional practice, phytochemistry, and the medical profile, thus identifying areas for research and future opportunities for research and development of this plant. All available information associated with Darunaj-Aqrabi in internationally recognised science repositories, including PubMed, Direct Science, Scopus, SciFinder, Google Scholar, Microsoft Academy, and Web Science, is searched. Additional information was collected in an old USM document on herbs, Unani Pharmacopoeia, and so on. These texts support its traditional use in formularies or by local people, such as digestion, carminative, child protection, cardiotonic, stomach tonic, liver tonic, lithotriptic, antidote, etc. The main phytochemical elements are alkaloids, saponins, flavonoids, photoactive thiophenes, sesquiterpene alcohol, paralianchol, and its acetophenone. There is limited information available on this plant. The review studies support its use as a digestive, carminative, child protection, cardiotonic, stomach tonic, liver tonic, lithotriptic, antidote, etc. However, many features of this tool are still unknown. In line with this, there’s insufficient detail in phytochemistry and a toxic profile. Thanks to the widespread use of Darunaj-aqrabi, further research into its pharmaceutical activities, phytochemistry, toxicity, and side effects is required to work out its therapeutic value.

Keywords: darunaj-aqrabi, darawnay, antibacterial, antifungal, antioxidant and hepatoprotective etc……..

The present study aims to formulate and evaluate ketoprofen transdermal patches containing different polymer components. We formulated four formulas for the transdermal matrix patches of ketoprofen, using polyethylene glycol 400, HPMC, and ethyl cellulose as the polymers. These patches were evaluated for various physicochemical characteristics and drug content. In this study, ethyl cellulose (EC) and hydroxypropyl methylcellulose (HPMC) were used as polymers to create matrix-type transdermal drug delivery systems (TDDS) for the drugs of interest. Five formulations were prepared using different concentrations of the polymers, either alone or in combination. The in-vitro permeation profiles and physicochemical properties suggest that the films from batch F1, prepared with HPMC, showed better release, with 76.56% of ketoconazole permeated across the skin at the end of 12 hours. In contrast, batch F2, prepared with EC, exhibited better-controlled release, with 45.11% permeated at the end of 12 hours.

Keywords: antifungal, ketoconazole, transdermal patches, topical, drug delivery, and polymers etc……..