Research in Pharmacy and Health Sciences

ISSN: 2455 5258
An International Peer Review Journal

Volume 4, Issue 2: April 2018- June 2018

1.The quality of life assessment of chronic schizophrenia and diabetic patients with WHO-QOL in Indian population: a comparative study
Sreelakshmi Sreedhar*, Aswini B, Neethu Poulose, Akhil Hari, P N Sureshkumar
Background: Schizophrenia is a chronic, severe and disabling psychiatric disorder and diabetes mellitus is one of the most prevalent non-psychiatric chronic illnesses. Both the diseases have common features of their chronicity, economic burden and dysfunction of occupation. QOL becomes more important health outcome tool in disorders that are chronic or where treatment continues over a long period. Methodology: In this study, descriptive survey was used to collect the data. Demographics details, laboratory results, given drugs, medical and medication history were documented into the data entry form and were asked to fill the BREF WHOQOL questionnaires (Malayalam version). Results: The BREF WHOQOL score was high in the Diabetic group in all the four domains as compared with the Schizophrenia group. Since P value is less than .05 in all cases, the difference is statistically significant. Discussion: The schizophrenia patients may have problems in maintaining relationships, frustration in working place, social isolation and stigma which again make their QoL scores lower especially when compared to a chronic physical illness like diabetes. The low score in schizophrenia indicates that mental illness influence above components of this domain. Conclusion: Mental health care is an integral part of healthcare. psychiatric illnesses is associated with lower QoL.

2. Probiotics for Oral Health: Boon or Bane
Nitish Bhat*, Sucheta Bansal, Kalpna Thakur, Ankit Rawat, Sunny Sharma, Narendra Singh
Probiotics are been widely used these days in diseases of the gut to combat the effect of medications and to provide a better beneficial microflora for the Gastrointestinal tract (GIT). The use of probiotics in maintaining an oral health has been widely discussed as the beneficial bacterial could replace the cariogenic and other bacterial which affect the oral health and prove a boon for oral health. The main strains used in GIT include Lactobacillus Species which are known to produce acids and can cause a reciprocal effect on the oral cavity. So everything which seems good is not a boon it might also have some ill effects which can be misery full and prove bane. This review demonstrates the action of Probiotics on oral health and disease with both beneficial and harmful effects.

3. The Notion of Platform-Switching in Implants: A Review
Ankit Rawat, Rupinder Singh Dhall, Nitish Bhat, Shivika Ahluwalia, Novika Sahni, Sunny Sharma, Narender Singh*
Platform switching implies to the mismatch in diameter of the abutment and that of the implant collar or in particular, use of the abutments with lesser diameter on a greater diameter implant collar. Platform switching was proposed as a process to improve long-term bone maintenance around implants. The clinical applications of platform switching are multiple, and all indicate better long-term predictability in implant therapy by allowing preservation of the peri-implant hard and soft tissue with time. In this review the influence of platform switching on various other factors affecting crestal bone loss around implants has been discussed.

4. Curing Asthma with Diet and Lifestyle Modification
Rai Waqas Ali, Umair Dar, Izzatullah Khan1, Asim Farooq, M. Soban, Zafeer Naeem Wain, Umer Tahir, Irfan Bashir
Asthma means chronic (long term) illness of the lungs causing cough, shortness of breath, chest tightness, wheezing and fast respirations, which is influenced by several genetic developments and environmental factors that affect over 300 million people around the world and 1 in 4 urban children. The occurrence of asthma increased in the world over the last 25 years. Environmental factors such as air pollution allergens, infection, smoking, hormones, and some specific medicine take part in this disorder. Currently there are different therapies to overcome this disease like Herbal, Unani, Ayurveda, Siddha, Homeopathy, Naturopathy, Allopathy, Biochemical and Chinese herbs. Allopathic treatment is also available for majority of the disorders but the problem is increasing price of medication now a days and allopathic medicines are related with a diversity of side effects. So tendency towards management of asthma with modern therapies like intake of nutritional diet and modification in our lifestyle including exercise, yoga are highly adopted these days.

5. Isolation of Bacteriophage from Guheswori Sewage Treatment Plant Capable of Infecting Pathogens
Bikram Gautam*, Lomas Aryal, Sachana Adhikari, Manoj Rana, AnjitaRajbhanshi, Sunita Ghale, Rameshwar Adhikari
Background: Waste water contains microorganisms which are continuously shed in the feces. These microorganisms especially bacteria might acquire antibiotic resistance and pose a significant threat to human health. Therefore, this work aims at isolating bacteriophage capable of infecting the isolated bacteria. Methodology: For this purpose, the grab sampling was performed at the Guheswori sewage treatment plant from the inlet in the primary treatment plant and from the outlet of the secondary treatment plant. For the isolation of bacteriophage, bacteriophage in the sewage was first enriched in an isolated pathogen, then filtered and then subjected to the isolates in the nutrient agar. Results: Pathogens like Escherichia coli, Salmonella Typhi, Enterococcus faecalis, Staphylococcus aureus, Coagulase negative Staphylococcus (CONS), Citrobacter fruendii, Enterobacter aerogenes, Proteus mirabilis, P. vulgaris, Pseudomonas aeruginosa were screened. Bacteriophage was able to infect E. coli (p < 0.001), S. Typhi (p < 0.001), E. faecalis (p = 0.182); and unable to infect S. aureus, CONS, C. fruendii, E. aerogenes, P. mirabilis, P. vulgaris, P. aeruginosa. Conclusion: Bacteriophage are able to infect and kill pathogens like E. coli, S. Typhi, E. faecalis and unable to infect S. aureus, CONS, C. fruendii, E. aerogenes, P. mirabilis, P. vulgaris, P. aeruginosa. Among all other reasons of lowering bacterial load, bacteriophages could also be one of the confounding factor. Such bacteriophage able to infect and undergo lytic cycle could be used in phage typing.

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