1. Incretins mimetic effects of Herbal drugs for management of Diabetes Mellitus: A research based approach Mohammad Nazrul Islam, AKM Nur Hossain, Md. Abu Taher, Mohammad Abu Bin Nyeem https://doi.org/10.32463/rphs.2017.v03i01.01
Insulin is a lifesaving hormone which is secreted from beta cell of Pancreas. It helps to reduce high blood sugar in the blood by trapping the glucose molecule and enter into cell. Now a day, insulin resistance diabetes mellitus (IRDM) becomes a serious public health problem in the world and also a great headache to the scientific communities. That’s why, world scientist are enormously seeking the alternative of insulin or insulin like effective drugs. It has been proved that nature is having all remedies to combat disease related morbidity and mortality. We have to search, we have to know, we have to identify and we have to apply appropriate technology to evaluate new molecules, new metabolites or active compounds for reducing the devastating effects of diabetes as well as insulin resistance diabetes mellitus. Evidence based studies showed that berbery, bitter melon, cinnamon tree, gardenia, korean pine, little dragon, mango, pygeum, fenugreek and lychee composed of incretins mimetic compounds. But isolation of active metabolomics and the multicentre base clinical trials are needed to propagate the herbal medicine in the world. It is an attempt to amalgamate, to congregate, to concise some incretins mimetic medicinal plants which will help to get new generic compound and also give new clue for further research on DM.
Background: Infertility is defined as the inability to conceive after at least one year of unprotected intercourse. It is a complex disorder with significant medical, psychosocial, and economic problems. In about one third of couples are infertile. Approximately 167 million married women aged 15-49 years in developing countries were infertility. The present study aimed to determine the most common causes of female infertility in patients who visiting the National Ayuvedic Teaching Hospital, Borella, Sri Lanka. Methods: In this study 635 infertile (primary and secondary) women were selected to determine the causes of infertility. The subjects were selected from the gynecology clinic, between the periods of February 2015 to March 2016. The data were gathered using a questionnaire; and after that proper statistical method was applied to analyze the data. Results: From the results age between 28-37 years (37.16%) are more prevalent to infertility and the causes of infertility are mainly due to anovulatory cycle (31.18%) and menstrual irregularities (19.21%). BMI also one of the significant cause for infertility. Conclusion: Therefore, identifying the risk factors and proper treatment on time along with policy makers providing facilities to resolve the infertility could possible diverse this alarming increasing trend of infertility.
Tramadol is a synthetic analogue of codeine which has been in the market since 1995. It is a racemic mixture in which the each of the enantiomer is responsible for each of its dual analgesic mechanism. The seizure inducing effect of tramadol is widely studied and reported. The tramadol can provoke seizure in patients with epilepsy and those with no history of epilepsy even with the recommended doses. The other precipitating factors are excessive doses or co-administration with other seizure inducing drugs.
Chitin is the most important natural polysaccharide after cellulose, found in crustaceous shell or in cell walls of fungi. Chitosan, one of the natural multifunctional polymers, due to its unique and versatile biological properties is regarded as a useful compound in medical and pharmaceutical technology. In recent times chitosan has been far and wide used as a popular formulation excipient due to its inimitable characteristics in the field of pharmaceutical sciences as binding, disintegrating, stabilizing, suspending, tablet coating, and film forming material. Recently, considerable research effort has been made in order to develop safe and efficient chitosan products. Chitosan has been comprehensively investigated for its suitability for its controlled release characteristics in various studies. Oral delivery of genes and peptides by means of different formulations based on chitosan is also investigated in various examinations by the capability of its absorption and penetration enhancing properties. It is possessing tremendous mucoadhesive and inherent anti-microbial properties, so that it can be used as a carrier for novel drug delivery. In addition to the above mentioned reasons, tailoring the controlled release and to improve the therapeutic efficacy of the low molecular weight drug compounds can also be achieved by this polymer and moreover in combination with various polymers is feasible due its compatibility i.e. low chemical reactivity. This brief editorial epitomizes the potential applications of chitosan in novel drug delivery systems.
Sturge–Weber syndrome (SWS) belongs to a group of disorders collectively known as the phakomatoses. It consists of congenital hamartomatous malformations that may affect the eye, skin, and central nervous system (CNS) at different times, characterized by the combination of venous angiomas of leptomeninges, face, jaws and oral soft tissues. SWS is referred to as complete when both central nervous system and facial angiomas are present, and incomplete when only one area is affected. Epilepsy is the most common and often the first neurological complication of SWS. Here we present a case of seizure with hypocalcaemia to the risk of Sturge weber syndrome. Brain – MRI with contrast, however, be advised that due to the progressive nature of SWS, brain involvement may not be evident on early scans. So initially child was treated for seizures with anti-epileptic drugs. The health professionals have to be suitably able to recognize its characteristic signs and symptoms, and so improve the quality of life of the patients.
Blood pressure or hypertension has become one of the leading medical issues among people all over the world. High blood pressure, if not controlled can lead to a many other related problems. Among them are kidney disease, heart failure, eye problems, strokes, and heart attacks. Alternative traditional regimes have proved to be highly successful in lowering high blood pressure and also promoting good health and wellness among patients. Hypertension or high blood pressure is typically caused when the blood thickens and becomes heavier over time. However in few people also have a larger volume of blood circulating in their bodies that causes blood pressure levels to rise. Cupping therapy and steam bath are non-invasive form of treatment, and works to eliminate the root causes of high blood pressure and draw out the thick and stagnant blood so that pure, light blood can circulate more freely.